{"count":2891,"next":"https://web/drugs/?page=2","previous":null,"results":[{"id":274648,"small_molecule":"Aidi injection ","fda_approved":false,"detection_method":"Microarray","condition":"human breast cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/21563499","reference":"Aidi injection alters the expression profiles of microRNAs in human breast cancer cells.","expression_pattern":"up-regulated","support":"Among them, 45 miRNAs were upregulated and 55 miRNAs were down-regulated significantly (P<0.05), miRNAs down-regulated being more than up-regulated for ADI treatment."},{"id":274649,"small_molecule":"Lenalidomide","fda_approved":true,"detection_method":"Quantitative real-time PCR","condition":"peripheral blood CD14+ monocytes","pubmed":"https://pubmed.ncbi.nlm.nih.gov/25287904","reference":"Genome-wide miRNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide","expression_pattern":"down-regulated","support":"Of these,6 miRNAs were upregulated (miR-34a*, miR-34a, miR-451, HS_241.1, miR-196b, and miR-98) and 14 were downregulated (eg, miR-449a, miR-193a-3p, miR-300, miR-378*, let-7i*, and miR-15a*) in patients vs controls."},{"id":274650,"small_molecule":"Caudatin","fda_approved":false,"detection_method":"Quantitative real-time PCR","condition":"gastric carcinoma cell lines","pubmed":"https://pubmed.ncbi.nlm.nih.gov/23708208","reference":"Caudatin induces cell apoptosis in gastric cancer cells through modulation of Wnt/β-catenin signaling.","expression_pattern":"up-regualted","support":"caudatin downregulated the expression of oncomir miR‑372 and miR‑21, and upregulated tumor suppressor let‑7a miRNA expression"},{"id":274651,"small_molecule":"XMD8-92","fda_approved":false,"detection_method":"Microarray","condition":"pancreatic ductal adenocarcinoma cell","pubmed":"https://pubmed.ncbi.nlm.nih.gov/24880079","reference":"XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism","expression_pattern":"up-regulated","support":"we showed that XMD8-92 inhibits AsPC-1 cancer cell proliferation and tumor xenograft growth. XMD8-92 treated tumors demonstrated significant downregulation of DCLK1 and several of its downstream targets (including c-MYC, KRAS, NOTCH1, ZEB1, ZEB2, SNAIL, SLUG, OCT4, SOX2, NANOG, KLF4, LIN28, VEGFR1, and VEGFR2) via upregulation of tumor suppressor miRNAs let-7a, miR-144, miR-200a-c, and miR-143/145"},{"id":274652,"small_molecule":"Hydroxamic acid HDACi LAQ824","fda_approved":false,"detection_method":"Microarray","condition":"breast cancer cell line SKBr3","pubmed":"https://pubmed.ncbi.nlm.nih.gov/16452179","reference":"Rapid alteration of microRNA levels by histone deacetylase inhibition.","expression_pattern":"down-regulated","support":"As shown in the Fig. 1B heat map, following LAQ824 treatment, the expression level of many SKBr3 miRNAs were altered with 22 miRNAs down-regulated and 5 miRNAs up-regulated."},{"id":274653,"small_molecule":"Hydroxamic acid HDACi LAQ824","fda_approved":false,"detection_method":"Northern blot","condition":"breast cancer cell line SKBr3","pubmed":"https://pubmed.ncbi.nlm.nih.gov/16452180","reference":"Rapid alteration of microRNA levels by histone deacetylase inhibition.","expression_pattern":"down-regulated","support":"As shown in Fig. 1C, Northern blots showing the up-regulation of miR-320 and the down-regulation of let7a and miR-27a following LAQ824 treatment confirmed the miRNA microarray result for these miRNAs. "},{"id":274654,"small_molecule":"Trichostatin A (TSA)","fda_approved":false,"detection_method":"Microarray","condition":"human pancreatic cancer cell line BxPC-3","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19112422","reference":"Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3.","expression_pattern":"down-regulated","support":"In our experiment, using miRNA microarray analysis,we found that 6 h treatment of cells with TSA inducedaltered expression of miRNAs: 29 miRNAs includingmiR-21, -181b, -181d, -221, -126, -375, let-7a, and let-7cwere significantly down-regulated and miR-200c, -100,-34a, -146a, and -146b were up-regulated. "},{"id":274655,"small_molecule":"17beta-estradiol (E2)","fda_approved":true,"detection_method":"Microarray","condition":"MCF-7 breast cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19528081","reference":"Estradiol-regulated microRNAs control estradiol response in breast cancer cells.","expression_pattern":"up-regulated","support":"To investigate this possibility, we determined microRNA-expression patterns in MCF-7p and MCF-7AKT cells with and without E2 treatment for 4 h. We observed 21 E2-inducible and 7 E2-repressible microRNAs in MCF-7p cells (statistical cutoff P-value <0.05 and fold change >1.5 or <0.7) (Table 1)."},{"id":274656,"small_molecule":"Etoposide","fda_approved":true,"detection_method":"Microarray","condition":"Normal human fibroblasts (AG01522)","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19633716","reference":"Ionizing radiation-induced oxidative stress alters miRNA expression.","expression_pattern":"down-regulated","support":"A more extensive analysis also determined that all 17 miRNA species altered by radiation were also altered by either H2O2 or etoposide (Table 1). Several species were altered only by etoposide or H2O2 (Fig. 2)."},{"id":274657,"small_molecule":"Etoposide","fda_approved":true,"detection_method":"Quantitative real-time PCR","condition":"Normal human fibroblasts (AG01522)","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19633716","reference":"Ionizing radiation-induced oxidative stress alters miRNA expression.","expression_pattern":"down-regulated","support":"A more extensive analysis also determined that all 17 miRNA species altered by radiation were also altered by either H2O2 or etoposide (Table 1). Several species were altered only by etoposide or H2O2 (Fig. 2)."}]}