{"count":27,"next":"https://web/drugs/?mirna=miR-126&page=2","previous":null,"results":[{"id":275014,"small_molecule":"Calcitriol","fda_approved":true,"detection_method":"Quantitative real-time PCR","condition":"human umbilical vein endothelial cells ","pubmed":"https://pubmed.ncbi.nlm.nih.gov/24397367","reference":"Vitamin D manipulates miR-181c, miR-20b and miR-20a in human umbilical vein endothelial cells exposed to a diabetic-like environment","expression_pattern":"up-regulated","support":"MiR-181c, miR-15a, miR-20b, miR-411, miR-659, miR-126 and miR-510 were selected for further analysis because they are known to be modified in DM and in other biological disorders."},{"id":275015,"small_molecule":"5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA)","fda_approved":false,"detection_method":"Microarray","condition":"T24 human bladder cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/16766263","reference":"Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.","expression_pattern":"up-regulated","support":"The combination treatment with 5-Aza-CdR and PBA showed that 17 out of 313 (5.4%) human miRNAs examined were upregulated more than 3-fold in T24 cells (Figure 1A)."},{"id":275016,"small_molecule":"Trichostatin A (TSA)","fda_approved":false,"detection_method":"Microarray","condition":"human pancreatic cancer cell line BxPC-3","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19112422","reference":"Effect of trichostatin a on viability and microRNA expression in human pancreatic cancer cell line BxPC-3.","expression_pattern":"down-regulated","support":"In our experiment, using miRNA microarray analysis,we found that 6 h treatment of cells with TSA inducedaltered expression of miRNAs: 29 miRNAs includingmiR-21, -181b, -181d, -221, -126, -375, let-7a, and let-7cwere significantly down-regulated and miR-200c, -100,-34a, -146a, and -146b were up-regulated. "},{"id":275017,"small_molecule":"Paclitaxel","fda_approved":true,"detection_method":"Microarray","condition":"ovarian cancer ","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19237188","reference":"MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy.","expression_pattern":"up-regulated","support":"Overall, linear regression analysis identified a total of 27 miRNAs(Table 1) that were significantly associated with OVCA cell responsiveness to one or more chemotherapeutic agents in the 16 cell lines."},{"id":275018,"small_molecule":"Vorinostat (SAHA)","fda_approved":true,"detection_method":"Microarray","condition":"A549 human non-small cell lung cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19513533","reference":"Suberoylanilide hydroxamic acid (SAHA) changes microRNA expression profiles in A549 human non-small cell lung cancer cells.","expression_pattern":"up-regulated","support":"To  further  confirm  that  miRNA  expression  patterns  are affected by the SAHA dose, we analyzed 227 flagged miRNAs and removed those that did not demonstrate a 2-fold change in  expression  levels  by  comparing  the  control,  2.5  um  and 5.0  um  treated  cells.  A total  of  64  miRNAs  were  selected for  further  study  (Table  I)  and  their  expression  profiles  are shown  in  Fig.  2A. "},{"id":275019,"small_molecule":"17beta-estradiol (E2)","fda_approved":true,"detection_method":"Microarray","condition":"MCF-7AKT breast cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/19528081","reference":"Estradiol-regulated microRNAs control estradiol response in breast cancer cells.","expression_pattern":"down-regulated","support":"To investigate this possibility, we determined microRNA-expression patterns in MCF-7p and MCF-7AKT cells with and without E2 treatment for 4 h. We observed 21 E2-inducible and 7 E2-repressible microRNAs in MCF-7p cells (statistical cutoff P-value <0.05 and fold change >1.5 or <0.7) (Table 1)."},{"id":275020,"small_molecule":"Mistletoe lectin-I ","fda_approved":false,"detection_method":"Microarray","condition":"colorectal cancer cells CLY cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/20955366","reference":"Down-regulation of some miRNAs by degrading their precursors contributes to anti-cancer effect of mistletoe lectin-I.","expression_pattern":"down-regulated","support":"Among the 428 human mature miRNAs analysed, 22 miRNAs were found to be down-regulated by more than twofold as compared with controls in CM-1-treated CLY cells, and 18 in CM-1-treated HT-29 cells (Table S2). "},{"id":275021,"small_molecule":"Formaldehyde","fda_approved":false,"detection_method":"Microarray","condition":"Human lung epithelial cells (A549)","pubmed":"https://pubmed.ncbi.nlm.nih.gov/21147603","reference":"Epigenetic changes induced by air toxics formaldehyde exposure alters miRNA expression profiles in human lung cells.","expression_pattern":"down-regulated","support":"A total of 89 miRNAs showed a significant decrease in expression in the formaldehyde-exposed lung samples compared with control samples [Figure 1; see also Supplemental Material, Table 1 (doi:10.1289/ehp.1002614)]."},{"id":275022,"small_molecule":"Enoxacin","fda_approved":true,"detection_method":"Quantitative real-time PCR","condition":"HCT-116 and RKO colon cancer cell lines ","pubmed":"https://pubmed.ncbi.nlm.nih.gov/21368194","reference":"Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing.","expression_pattern":"up-regulated","support":"We observed that HCT-116 and RKO enoxacin-treated cells featured an overall increase in the production of 24 mature miRNAs molecules (Fig. 2A) and a down-regulation of the corresponding precursor miRNA molecules (Fig. S2). "},{"id":275023,"small_molecule":"Aidi injection ","fda_approved":false,"detection_method":"Microarray","condition":"human breast cancer cells","pubmed":"https://pubmed.ncbi.nlm.nih.gov/21563499","reference":"Aidi injection alters the expression profiles of microRNAs in human breast cancer cells.","expression_pattern":"up-regulated","support":"Among them, 45 miRNAs were upregulated and 55 miRNAs were down-regulated significantly (P<0.05), miRNAs down-regulated being more than up-regulated for ADI treatment."}]}